A analysis group led by Prof. Wang Hui from the Hefei Institutes of Bodily Science (HFIPS) of the Chinese language Academy of Sciences has launched a metal-free nanozyme primarily based on graphene quantum dots (GQDs) for extremely environment friendly tumor chemodynamic remedy (CDT). The research is revealed in Matter.
GQDs signify a promising and cost-effective technique of addressing the toxicity issues related to metal-based nanozymes in tumor CDT. Nonetheless, the restricted catalytic exercise of GQDs has posed important challenges for his or her medical utility, significantly underneath difficult catalytic circumstances.
“The obtained GQDs, that are comprised of crimson blood cell membranes, are extremely efficient in treating tumors with few unwanted effects,” mentioned Liu Hongji, a member of the analysis workforce. “One of many benefits is that they’re metal-free. As well as, they operate as glorious peroxidase-like biocatalysts.”
To reinforce the catalytic efficiency of the GQD-based nanocatalytic adjuvant, the researchers rationally designed GQDs utilizing a diatomic doping technique. The synergistic electron impact of introducing nitrogen and phosphorus into GQDs can generate extremely localized states close to the Fermi degree, thus enabling environment friendly enzymatic exercise in comparison with single heteroatom doping.
The obtained GQDs, derived from erythrocyte membranes, have been proven to own spectacular peroxidase-mimicking exercise. In consequence, the GQDs are extremely efficient at inducing apoptosis and ferroptosis of most cancers cells in vitro. Additionally they selectively goal tumors, with a tumor inhibition price as excessive as 77.71% for intravenous injection and 93.22% for intratumoral injection, with no off-target unwanted effects.
This drug-free, target-specific, and biologically benign nanozyme has nice potential as a potent biocatalyst to be used in secure most cancers therapy.
Extra info:
Graphene quantum dots as metal-free nanozymes for chemodynamic remedy of most cancers, Matter (2024). DOI: 10.1016/j.matt.2023.12.005. www.cell.com/matter/fulltext/S2590-2385(23)00619-7
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Steel-free graphene quantum dots present promise for extremely environment friendly tumor remedy (2024, January 10)
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