Trendy computational expertise based mostly on von Neumann structure bodily partitions reminiscence and central processing unit, leading to basic velocity limitations and excessive vitality consumption. Alternatively, the human mind is a rare multifunctional organ composed of greater than a billion neurons able to concurrently pondering, processing, and storing data. Neurons are interconnected with synapses that management data circulate from pre-synaptic-to-post-synaptic neurons. Subsequently, emulating synaptic functionalities and growing neuromorphic computational structure has just lately attracted a lot curiosity. As a consequence of their high-speed, massive bandwidth, and no interconnect-related energy loss, photonic (all-optical) synapses can overcome the present hurdles with digital synapses. Right here, we present a synthetic photonic synapse by using the well-established reversible, high-contrast photochromic natural compound, spiropyran, stimulated by optical pulses. Optical transmission of spiropyran considerably adjustments throughout spiropyran-merocyanine isomerization pushed by the UV-visible optical pulses. Such adjustments are equal to the organic synapses’ inhibitory and excitatory synaptic actions. The gradual leisure to the preliminary state is taken into account synaptic plasticity answerable for studying and reminiscence formation. Quick-term reminiscence (STM), long-term reminiscence (LTM), and transition from the STM to LTM are demonstrated in all-optical synapses by modulating the stimuli’ power. The solvatochromic properties of spiropyran are additional utilized to reinforce reminiscence in synapses. Our work reveals that photochromic natural compounds are glorious hosts for synthetic photonic synapses and could be applied in neuromorphic functions.