With the present developmental developments in nanotechnology, nanofibrous scaffolds are being extensively used. The therapeutic of fibrocartilaginous enthesis is a gradual and complicated course of, and whereas present remedies have a sure impact on selling their therapeutic, these are related to some limitations. The nanofibrous scaffold has some great benefits of simple preparation, large supply of uncooked supplies, simple adjustment, simple modification, can mimic the pure construction and morphology of the fibrocartilaginous enthesis, and has good biocompatibility, which may compensate for present remedies and be mixed with them to advertise the restore of fibrocartilaginous enthesis. The nanofibrous scaffold can promote the therapeutic of fibrocartilaginous enthesis by controlling the morphology and guaranteeing managed drug launch. Therefore, using nanofibrous scaffold with stimulative response options within the musculoskeletal system has led us to think about its potential software in fibrocartilaginous enthesis. Subsequently, the therapeutic of fibrocartilaginous enthesis based mostly on a nanofibrous scaffold could also be a novel therapeutic strategy.