The sphere of nanomaterials has progressed dramatically over the previous a long time with vital contributions to the biomedical space. The physicochemical properties of nanomaterials, similar to measurement and construction, could be managed by way of manipulation of mass and warmth switch situations throughout synthesis. Particularly, microfluidic techniques with speedy mixing and exact fluid management are perfect platforms for creating acceptable synthesis situations. One notable instance of microfluidics-based synthesis is the event of lipid nanoparticle (LNP)-based mRNA vaccines with accelerated medical translation and sturdy efficacy throughout the COVID-19 pandemic. Along with LNP, microfluidic techniques have been adopted for the managed synthesis of a broad vary of nanomaterials. On this assessment, we introduce the basic ideas of microfluidic applied sciences together with movement field- and a number of field-based strategies for fabricating nanoparticles, and talk about their purposes within the biomedical area. We conclude this assessment by outlining a number of main challenges and future instructions within the implementation of microfluidic synthesis of nanomaterials.