Floor-enhanced infrared absorption (SEIRA) results in a largely improved detection of polar molecules, in comparison with commonplace infrared absorption. The enhancement precept is predicated on localized floor plasmon resonances of the substrate, which match the frequency of molecular vibrations within the analyte of curiosity. Due to this fact, in sensible phrases, the SEIRA sensor must be tailor-made to every particular analyte. We evaluation SEIRA sensors based mostly on metallic plasmonics for the detection of biomolecules similar to DNA, proteins, and lipids. We additional focus this evaluation on chemical SEIRA sensors, with potential purposes in high quality management, in addition to on the development in sensor geometry that led to the event of multiresonant SEIRA substrates as sensors for a number of analytes. Lastly, we give an introduction into the mixing of SEIRA sensors with surface-enhanced Raman scattering (SERS).