The distinctive solid-solution construction and multi-element compositions of high-entropy alloy nanoparticles (HEA NPs) have garnered substantial consideration. Varied strategies have been developed to organize a various array of HEA NPs utilizing completely different substrates for assist and stabilization. On this examine, we current a facile surface-mediated discount methodology to organize HEA NPs (AuAgCuPdPt) adorned germanane (HEA NPs@GeNSs), and make use of X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM) to characterize their construction, composition, and morphology. Subsequently, we exhibit that the HEA NPs may be liberated from the surfaces of GeNSs as freestanding methods through simple publicity to UV mild. We additionally discover germanium nanoparticles (GeNPs) as a substitute substrate for HEA NP formation/manufacturing, given their similarity to germanane and their Ge–H floor. Lastly, we prolong our investigation to bulk Ge wafers and exhibit profitable deposition of HEA NPs.