Kurokawa M, Kornbluth S. Caspases and kinases in a demise grip. Cell. 2009;138(5):838–54.
Liu D, Kou X, Chen C, Liu S, Liu Y, Yu W, Yu T, Yang R, Wang R, Zhou Y, Shi S. Circulating apoptotic our bodies keep mesenchymal stem cell homeostasis and ameliorate osteopenia through transferring a number of mobile elements. Cell Res. 2018;28(9):918–33.
Hauser P, Wang S, Didenko VV. Apoptotic our bodies: selective detection in extracellular vesicles. Strategies Mol Biol. 2017;1554:193–200.
Battistelli M, Falcieri E. Apoptotic our bodies: specific extracellular vesicles concerned in intercellular communication. Biology. 2020;9(1):21.
Xu X, Lai Y, Hua ZC. Apoptosis and apoptotic physique: illness message and therapeutic goal potentials. Biosci Rep. 2019;39(1): BSR20180992.
Liu H, Liu S, Qiu X, Yang X, Bao L, Pu F, Liu X, Li C, Xuan Ok, Zhou J, Deng Z, Liu S, Jin Y. Donor MSCs launch apoptotic our bodies to enhance myocardial infarction through autophagy regulation in recipient cells. Autophagy. 2020;16(12):2140–55.
Atkin-Smith GK, Duan M, Zanker DJ, Loh L, Nguyen THO, Koutsakos M, Nguyen T, Jiang X, Carrera J, Phan TK, Liu C, Paone S, Oveissi S, Hodge AL, Baxter AA, Kedzierska Ok, Mackenzie JM, Hulett MD, Bilsel P, Chen W, Poon IKH. Monocyte apoptotic our bodies are autos for influenza A virus propagation. Commun Biol. 2020;3(1):223.
Yuan FL, Xu RS, Ye JX, Zhao MD, Ren LJ, Li X. Apoptotic our bodies from endplate chondrocytes improve the oxidative stress-induced mineralization by regulating PPi metabolism. J Cell Mol Med. 2019;23(5):3665–75.
Berda-Haddad Y, Robert S, Salers P, Zekraoui L, Farnarier C, Dinarello CA, Dignat-George F, Kaplanski G. Sterile irritation
of endothelial cell-derived apoptotic our bodies is mediated by interleukin-1α. Proc Natl Acad Sci USA. 2011;108(51):20684–9.
Schwartz YS, Dolganova OM, Rudina MI, Pyshnaya IA, Bgatova NP. Affect of apoptotic our bodies and apoptotic microvesicles on NO manufacturing in macrophages. Bull Exp Biol Med. 2018;165(4):453–6.
Fransen JH, Hilbrands LB, Ruben J, Stoffels M, Adema GJ, van der Vlag J, Berden JH. Mouse dendritic cells matured by ingestion of apoptotic blebs induce T cells to provide interleukin-17. Arthritis Rheum. 2009;60(8):2304–13.
Eerola AK, Soini Y, Lehto VP, Paakko P. Elevated numbers of alveolar macrophages with apoptotic our bodies predict lung carcinoma. Apoptosis. 1998;3(4):261–6.
Brandel V, Schimek V, Gober S, Hammond T, Brunnthaler L, Schrottmaier WC, Mussbacher M, Sachet M, Liang YY, Reipert S, Ortmayr G, Pereyra D, Santol J, Rainer M, Walterskirchen N, Ramos C, Gerakopoulos V, Rainer C, Spittler A, Weiss T, Kain R, Messner B, Gruenberger T, Assinger A, Oehler R, Starlinger P. Hepatectomy-induced apoptotic extracellular vesicles stimulate neutrophils to secrete regenerative development elements. J Hepatol. 2022;77(6):1619–30.
Wang J, Cao Z, Wang P, Zhang X, Tang J, He Y, Huang Z, Mao X, Shi S, Kou X. Apoptotic extracellular vesicles ameliorate a number of myeloma by restoring Fas-mediated apoptosis. ACS Nano. 2021;15(9):14360–72.
Zheng C, Sui B, Zhang X, Hu J, Chen J, Liu J, Wu D, Ye Q, Xiang L, Qiu X, Liu S, Deng Z, Zhou J, Liu S, Shi S, Jin Y. Apoptotic vesicles restore liver macrophage homeostasis to counteract kind 2 diabetes. J Extracell Vesicles. 2021;10(7): e12109.
Ye Q, Xu H, Liu S, Li Z, Zhou J, Ding F, Zhang X, Wang Y, Jin Y, Wang Q. Apoptotic extracellular vesicles alleviate Pg-LPS induced irritation of macrophages through AMPK/SIRT1/NF-κB pathway and inhibit adjoining osteoclast formation. J Periodontol. 2022. https://doi.org/10.1002/JPER.21-0657.
Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL, Henson PM. Publicity of phosphatidylserine on the floor of apoptotic lymphocytes triggers particular recognition and removing by macrophages. J Immunol. 1992;148(7):2207–16.
Wu Y, Zhang Y, Dai L, Wang Q, Xue L, Su Z, Zhang C. An apoptotic body-biomimic liposome in situ upregulates anti-inflammatory macrophages for stabilization of atherosclerotic plaques. J Management Launch. 2019;316:236–49.
Bose RJC, Tharmalingam N, Garcia Marques FJ, Sukumar UK, Natarajan A, Zeng Y, Robinson E, Bermudez A, Chang E, Habte F, Pitteri SJ, McCarthy JR, Gambhir SS, Massoud TF, Mylonakis E, Paulmurugan R. Reconstructed apoptotic our bodies as focused “nano decoys” to deal with intracellular bacterial infections inside macrophages and most cancers cells. ACS Nano. 2020;14(5):5818–35.
Palma M, Hansson L, Choudhury A, Nasman-Glaser B, Eriksson I, Adamson L, Rossmann E, Widen Ok, Horvath R, Kokhaei P, Vertuani S, Mellstedt H, Osterborg A. Vaccination with dendritic cells loaded with tumor apoptotic our bodies (Apo-DC) in sufferers with persistent lymphocytic leukemia: results of assorted adjuvants and definition of immune response standards. Most cancers Immunol Immunother. 2012;61(6):865–79.
Zhao G, Liu H, Wang Z, Yang H, Zhao H, Zhang Y, Ge Ok, Wang X, Luo L, Zhou X, Zhang J, Li Z. Exosome transportation-mediated immunosuppression aid by cascade amplification for enhanced apoptotic physique vaccination. Acta Biomater. 2022;153:529–39.
Ruben JM, van den Ancker W, Bontkes HJ, Westers TM, Hooijberg E, Ossenkoppele GJ, de Gruijl TD, van de Loosdrecht AA. Apoptotic blebs from leukemic cells as a most popular supply of tumor-associated antigen for dendritic cell-based vaccines. Most cancers Immunol Immunother. 2014;63(4):335–45.
van Niel G, D’Angelo G, Raposo G. Shedding mild on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19(4):213–28.
Maacha S, Bhat AA, Jimenez L, Raza A, Haris M, Uddin S, Grivel JC. Extracellular vesicles-mediated intercellular communication: roles within the tumor microenvironment and anti-cancer drug resistance. Mol Most cancers. 2019;18(1):55.
Marar C, Starich B, Wirtz D. Extracellular vesicles in immunomodulation and tumor development. Nat Immunol. 2021;22(5):560–70.
Todorova D, Simoncini S, Lacroix R, Sabatier F, Dignat-George F. Extracellular vesicles in angiogenesis. Circ Res. 2017;120(10):1658–73.
van Niel G, Carter DRF, Clayton A, Lambert DW, Raposo G, Vader P. Challenges and instructions in finding out cell-cell communication by extracellular vesicles. Nat Rev Mol Cell Biol. 2022;23(5):369–82.
Cheng L, Hill AF. Therapeutically harnessing extracellular vesicles. Nat Rev Drug Discov. 2022;21(5):379–99.
Raposo G, Stahl PD. Extracellular vesicles: a brand new communication paradigm? Nat Rev Mol Cell Biol. 2019;20(9):509–10.
Mathieu M, Martin-Jaular L, Lavieu G, Thery C. Specificities of secretion and uptake of exosomes and different extracellular vesicles for cell-to-cell communication. Nat Cell Biol. 2019;21(1):9–17.
Mathivanan S, Ji H, Simpson RJ. Exosomes: extracellular organelles vital in intercellular communication. J Proteomics. 2010;73(10):1907–20.
Thery C, Boussac M, Veron P, Ricciardi-Castagnoli P, Raposo G, Garin J, Amigorena S. Proteomic evaluation of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J Immunol. 2001;166(12):7309–18.
Atkin-Smith GK, Tixeira R, Paone S, Mathivanan S, Collins C, Liem M, Goodall KJ, Ravichandran KS, Hulett MD, Poon IK. A novel mechanism of producing extracellular vesicles throughout apoptosis through a beads-on-a-string membrane construction. Nat Commun. 2015;6:7439.
Miyanishi M, Tada Ok, Koike M, Uchiyama Y, Kitamura T, Nagata S. Identification of Tim4 as a phosphatidylserine receptor. Nature. 2007;450(7168):435–9.
Durcin M, Fleury A, Taillebois E, Hilairet G, Krupova Z, Henry C, Truchet S, Trotzmuller M, Kofeler H, Mabilleau G, Hue O, Andriantsitohaina R, Martin P, Le Lay S. Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for giant and small extracellular vesicles. J Extracell Vesicles. 2017;6(1):1305677.
Wickman G, Julian L, Olson MF. How apoptotic cells support within the removing of their very own chilly useless our bodies. Cell Demise Differ. 2012;19(5):735–42.
Shamas-Din A, Kale J, Leber B, Andrews DW. Mechanisms of motion of Bcl-2 household proteins. Chilly Spring Harb Perspect Biol. 2013;5(4): a008714.
Elmore S. Apoptosis: a overview of programmed cell demise. Toxicol Pathol. 2007;35(4):495–516.
Hill MM, Adrain C, Duriez PJ, Creagh EM, Martin SJ. Evaluation of the composition, meeting kinetics and exercise of native Apaf-1 apoptosomes. Embo j. 2004;23(10):2134–45.
Chinnaiyan AM. The apoptosome: coronary heart and soul of the cell demise machine. Neoplasia. 1999;1(1):5–15.
Ashkenazi A, Dixit VM. Demise receptors: signaling and modulation. Science. 1998;281(5381):1305–8.
Hsu H, Xiong J, Goeddel DV. The TNF receptor 1-associated protein TRADD indicators cell demise and NF-kappa B activation. Cell. 1995;81(4):495–504.
Bedoui S, Herold MJ, Strasser A. Rising connectivity of programmed cell demise pathways and its physiological implications. Nat Rev Mol Cell Biol. 2020;21(11):678–95.
Igney FH, Krammer PH. Demise and anti-death: tumour resistance to apoptosis. Nat Rev Most cancers. 2002;2(4):277–88.
Mills JC, Stone NL, Erhardt J, Pittman RN. Apoptotic membrane blebbing is regulated by myosin mild chain phosphorylation. J Cell Biol. 1998;140(3):627–36.
Charras GT, Yarrow JC, Horton MA, Mahadevan L, Mitchison TJ. Non-equilibration of hydrostatic stress in blebbing cells. Nature. 2005;435(7040):365–9.
Croft DR, Coleman ML, Li S, Robertson D, Sullivan T, Stewart CL, Olson MF. Actin-myosin-based contraction is accountable for apoptotic nuclear disintegration. J Cell Biol. 2005;168(2):245–55.
Moss DK, Betin VM, Malesinski SD, Lane JD. A novel position for microtubules in apoptotic chromatin dynamics and mobile fragmentation. J Cell Sci. 2006;119(Pt 11):2362–74.
Poon IK, Chiu YH, Armstrong AJ, Kinchen JM, Juncadella IJ, Bayliss DA, Ravichandran KS. Sudden hyperlink between an antibiotic, pannexin channels and apoptosis. Nature. 2014;507(7492):329–34.
Barros LF, Kanaseki T, Sabirov R, Morishima S, Castro J, Bittner CX, Maeno E, Ando-Akatsuka Y, Okada Y. Apoptotic and necrotic blebs in epithelial cells show comparable neck diameters however completely different kinase dependency. Cell Demise Differ. 2003;10(6):687–97.
Orlando KA, Stone NL, Pittman RN. Rho kinase regulates fragmentation and phagocytosis of apoptotic cells. Exp Cell Res. 2006;312(1):5–15.
Núñez R, Sancho-Martínez SM, Novoa JM, López-Hernández FJ. Apoptotic quantity lower as a geometrical determinant for cell dismantling into apoptotic our bodies. Cell Demise Differ. 2010;17(11):1665–71.
Bortner CD, Sifre MI, Cidlowski JA. Cationic gradient reversal and cytoskeleton-independent quantity regulatory pathways outline an early stage of apoptosis. J Biol Chem. 2008;283(11):7219–29.
Ihara T, Yamamoto T, Sugamata M, Okumura H, Ueno Y. The method of ultrastructural adjustments from nuclei to apoptotic physique. Virchows Arch. 1998;433(5):443–7.
Aoki Ok, Satoi S, Harada S, Uchida S, Iwasa Y, Ikenouchi J. Coordinated adjustments in cell membrane and cytoplasm throughout maturation of apoptotic bleb. Mol Biol Cell. 2020;31(8):833–44.
Santavanond JP, Rutter SF, Atkin-Smith GK, Poon IKH. Apoptotic our bodies: mechanism of formation, isolation and useful relevance. Subcell Biochem. 2021;97:61–88.
Tixeira R, Phan TK, Caruso S, Shi B, Atkin-Smith GK, Nedeva C, Chow JDY, Puthalakath H, Hulett MD, Herold MJ, Poon IKH. ROCK1 however not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly. Cell Demise Differ. 2020;27(1):102–16.
Sebbagh M, Renvoizé C, Hamelin J, Riché N, Bertoglio J, Bréard J. Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nat Cell Biol. 2001;3(4):346–52.
Coleman ML, Sahai EA, Yeo M, Bosch M, Dewar A, Olson MF. Membrane blebbing throughout apoptosis outcomes from caspase-mediated activation of ROCK I. Nat Cell Biol. 2001;3(4):339–45.
Yang N, Higuchi O, Ohashi Ok, Nagata Ok, Wada A, Kangawa Ok, Nishida E, Mizuno Ok. Cofilin phosphorylation by LIM-kinase 1 and its position in Rac-mediated actin reorganization. Nature. 1998;393(6687):809–12.
Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard O, Caroni P. Regulation of actin dynamics by phosphorylation of cofilin by LIM-kinase. Nature. 1998;393(6687):805–9.
Phan TK, Fonseka P, Tixeira R, Pathan M, Ang CS, Ozkocak DC, Mathivanan S, Poon IKH. Pannexin-1 channel regulates nuclear content material packaging into apoptotic our bodies and their dimension. Proteomics. 2021;21(13–14): e2000097.
Caruso S, Atkin-Smith GK, Baxter AA, Tixeira R, Jiang L, Ozkocak DC, Santavanond JP, Hulett MD, Lock P, Phan TK, Poon IKH. Defining the position of cytoskeletal parts within the formation of apoptopodia and apoptotic our bodies throughout apoptosis. Apoptosis. 2019;24(11–12):862–77.
Chekeni FB, Elliott MR, Sandilos JK, Stroll SF, Kinchen JM, Lazarowski ER, Armstrong AJ, Penuela S, Laird DW, Salvesen GS, Isakson BE, Bayliss DA, Ravichandran KS. Pannexin 1 channels mediate “find-me” sign launch and membrane permeability throughout apoptosis. Nature. 2010;467(7317):863–7.
Elliott MR, Chekeni FB, Trampont PC, Lazarowski ER, Kadl A, Stroll SF, Park D, Woodson RI, Ostankovich M, Sharma P, Lysiak JJ, Harden TK, Leitinger N, Ravichandran KS. Nucleotides launched by apoptotic cells act as a find-me sign to advertise phagocytic clearance. Nature. 2009;461(7261):282–6.
Jiang L, Tixeira R, Caruso S, Atkin-Smith GK, Baxter AA, Paone S, Hulett MD, Poon IK. Monitoring the development of cell demise and the disassembly of dying cells by movement cytometry. Nat Protoc. 2016;11(4):655–63.
Zhang XD, Gillespie SK, Hersey P. Staurosporine induces apoptosis of melanoma by each caspase-dependent and -independent apoptotic pathways. Mol Most cancers Ther. 2004;3(2):187–97.
Di Nicola M, Napoli S, Anichini A, Mortarini R, Romagnoli L, Magni M, Matteucci P, Baldassarri P, Bersani I, Carlo-Stella C, Gianni AM. Dendritic cell viability is decreased after phagocytosis of apoptotic tumor cells induced by staurosporine or vaccinia virus an infection. Haematologica. 2003;88(12):1396–404.
Orozco AF, Bischoff FZ, Horne C, Popek E, Simpson JL, Lewis DE. Hypoxia-induced membrane-bound apoptotic DNA particles: potential mechanism of fetal DNA in maternal plasma. Ann N Y Acad Sci. 2006;1075:57–62.
Crescitelli R, Lässer C, Szabó TG, Kittel A, Eldh M, Dianzani I, Buzás EI, Lötvall J. Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic our bodies, microvesicles and exosomes. J Extracell Vesicles. 2013;2:20677.
Atkin-Smith GK, Paone S, Zanker DJ, Duan M, Phan TK, Chen W, Hulett MD, Poon IK. Isolation of cell type-specific apoptotic our bodies by fluorescence-activated cell sorting. Sci Rep. 2017;7:39846.
Bao L, Dou G, Tian R, Lv Y, Ding F, Liu S, Zhao R, Zhao L, Zhou J, Weng L, Dong Y, Li B, Liu S, Chen X, Jin Y. Engineered neutrophil apoptotic our bodies ameliorate myocardial infarction by selling macrophage efferocytosis and irritation decision. Bioact Mater. 2022;9:183–97.
Poon IKH, Parkes MAF, Jiang L, Atkin-Smith GK, Tixeira R, Gregory CD, Ozkocak DC, Rutter SF, Caruso S, Santavanond JP, Paone S, Shi B, Hodge AL, Hulett MD, Chow JDY, Phan TK, Baxter AA. Shifting past dimension and phosphatidylserine publicity: proof for a variety of apoptotic cell-derived extracellular vesicles in vitro. J Extracell Vesicles. 2019;8(1):1608786.
Xin L, Wei C, Tong X, Dai Y, Huang D, Chen J, Ma L, Zhang S. In situ supply of apoptotic our bodies derived from mesenchymal stem cells through a hyaluronic acid hydrogel: a remedy for intrauterine adhesions. Bioact Mater. 2022;12:107–19.
Yue TL, Wang C, Romanic AM, Kikly Ok, Keller P, DeWolf WE Jr, Hart TK, Thomas HC, Storer B, Gu JL, Wang X, Feuerstein GZ. Staurosporine-induced apoptosis in cardiomyocytes: a possible position of caspase-3. J Mol Cell Cardiol. 1998;30(3):495–507.
Thuret G, Chiquet C, Herrag S, Dumollard JM, Boudard D, Bednarz J, Campos L, Acquire P. Mechanisms of staurosporine induced apoptosis in a human corneal endothelial cell line. Br J Ophthalmol. 2003;87(3):346–52.
Belmokhtar CA, Hillion J, Ségal-Bendirdjian E. Staurosporine induces apoptosis by each caspase-dependent and caspase-independent mechanisms. Oncogene. 2001;20(26):3354–62.
Manns J, Daubrawa M, Driessen S, Paasch F, Hoffmann N, Löffler A, Lauber Ok, Dieterle A, Alers S, Iftner T, Schulze-Osthoff Ok, Stork B, Wesselborg S. Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 within the absence of Apaf-1. Faseb j. 2011;25(9):3250–61.
Mannequin MA, Mudrak NJ, Rana PS, Clements RJ. Staurosporine-induced apoptotic water loss is cell- and attachment-specific. Apoptosis. 2018;23(7–8):449–55.
Piwocka Ok, Zabłocki Ok, Wieckowski MR, Skierski J, Feiga I, Szopa J, Drela N, Wojtczak L, Sikora E. A novel apoptosis-like pathway, unbiased of mitochondria and caspases, induced by curcumin in human lymphoblastoid T (Jurkat) cells. Exp Cell Res. 1999;249(2):299–307.
Scoltock AB, Cidlowski JA. Activation of intrinsic and extrinsic pathways in apoptotic signaling throughout UV-C-induced demise of Jurkat cells: the position of caspase inhibition. Exp Cell Res. 2004;297(1):212–23.
Ma Q, Liang M, Wu Y, Ding N, Duan L, Yu T, Bai Y, Kang F, Dong S, Xu J, Dou C. Mature osteoclast-derived apoptotic our bodies promote osteogenic differentiation through RANKL-mediated reverse signaling. J Biol Chem. 2019;294(29):11240–7.
Distler JH, Huber LC, Hueber AJ, Reich CF third, Homosexual S, Distler O, Pisetsky DS. The discharge of microparticles by apoptotic cells and their results on macrophages. Apoptosis. 2005;10(4):731–41.
Tsoncheva VL, Milchev GI. Delayed reproductive demise and ROS ranges within the progeny of irradiated melanoma cells. Z Naturforsch C J Biosci. 2004;59(3–4):297–301.
Vieyra-Garcia PA, Wolf P. A deep dive into UV-based phototherapy: mechanisms of motion and rising molecular targets in irritation and most cancers. Pharmacol Ther. 2021;222: 107784.
Langevin SM, Kuhnell D, Orr-Asman MA, Biesiada J, Zhang X, Medvedovic M, Thomas HE. Balancing yield, purity and practicality: a modified differential ultracentrifugation protocol for environment friendly isolation of small extracellular vesicles from human serum. RNA Biol. 2019;16(1):5–12.
Rad F, Pourfathollah AA, Yari F, Mohammadi S, Kheirandish M. Microvesicles preparation from mesenchymal stem cells. Med J Islam Repub Iran. 2016;30:398.
Momen-Heravi F, Balaj L, Alian S, Mantel PY, Halleck AE, Trachtenberg AJ, Soria CE, Oquin S, Bonebreak CM, Saracoglu E, Skog J, Kuo WP. Present strategies for the isolation of extracellular vesicles. Biol Chem. 2013;394(10):1253–62.
Beillevaire D, Migneault F, Turgeon J, Gingras D, Rimbaud AK, Marcoux G, Spino C, Thibodeau N, Bonneil E, Thibault P, Boilard E, Dieude M, Hebert MJ. Autolysosomes and caspase-3 management the biogenesis and launch of immunogenic apoptotic exosomes. Cell Demise Dis. 2022;13(2):145.
Turiak L, Misjak P, Szabo TG, Aradi B, Paloczi Ok, Ozohanics O, Drahos L, Kittel A, Falus A, Buzas EI, Vekey Ok. Proteomic characterization of thymocyte-derived microvesicles and apoptotic our bodies in BALB/c mice. J Proteomics. 2011;74(10):2025–33.
Phan TK, Poon IK, Atkin-Smith GK. Detection and isolation of apoptotic our bodies to excessive purity. J Vis Exp. 2018. https://doi.org/10.3791/58317(138).
Zhou GF, Chen CX, Cai QC, Yan X, Peng NN, Li XC, Cui JH, Han YF, Zhang Q, Meng JH, Tang HM, Cai CH, Lengthy J, Luo KJ. Bracovirus sneaks into apoptotic our bodies transmitting immunosuppressive signaling pushed by integration-mediated eIF5A hypusination. Entrance Immunol. 2022;13: 901593.
Liu J, Qiu X, Lv Y, Zheng C, Dong Y, Dou G, Zhu B, Liu A, Wang W, Zhou J, Liu S, Liu S, Gao B, Jin Y. Apoptotic our bodies derived from mesenchymal stem cells promote cutaneous wound therapeutic through regulating the features of macrophages. Stem Cell Res Ther. 2020;11(1):507.
Henry F, Boisteau O, Bretaudeau L, Lieubeau B, Meflah Ok, Grégoire M. Antigen-presenting cells that phagocytose apoptotic tumor-derived cells are potent tumor vaccines. Most cancers Res. 1999;59(14):3329–32.
Nakamura Ok, Yuh Ok, Sugyo S, Kuroki M, Shijo H, Tamura Ok. Unresponsiveness of peripheral T cells induced by apoptotic our bodies derived from autologous T cells. Cell Immunol. 1999;193(2):147–54.
Jiang L, Paone S, Caruso S, Atkin-Smith GK, Phan TK, Hulett MD, Poon IKH. Figuring out the contents and cell origins of apoptotic our bodies by movement cytometry. Sci Rep. 2017;7(1):14444.
Akers JC, Gonda D, Kim R, Carter BS, Chen CC. Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic our bodies. J Neurooncol. 2013;113(1):1–11.
Taylor RC, Cullen SP, Martin SJ. Apoptosis: managed demolition on the mobile degree. Nat Rev Mol Cell Biol. 2008;9(3):231–41.
Li Z, Wu M, Liu S, Liu X, Huan Y, Ye Q, Yang X, Guo H, Liu A, Huang X, Yang X, Ding F, Xu H, Zhou J, Liu P, Liu S, Jin Y, Xuan Ok. Apoptotic vesicles activate autophagy in recipient cells to induce angiogenesis and dental pulp regeneration. Mol Ther. 2022;30(10):3193–208.
Li M, Xing X, Huang H, Liang C, Gao X, Tang Q, Xu X, Yang J, Liao L, Tian W. BMSC-derived ApoEVs promote craniofacial bone restore through ROS/JNK signaling. J Dent Res. 2022;101(6):714–23.
Schiller M, Bekeredjian-Ding I, Heyder P, Clean N, Ho AD, Lorenz HM. Autoantigens are translocated into small apoptotic our bodies throughout early phases of apoptosis. Cell Demise Differ. 2008;15(1):183–91.
Wang Y, Pang J, Wang Q, Yan L, Wang L, Xing Z, Wang C, Zhang J, Dong L. Delivering antisense oligonucleotides throughout the blood-brain barrier by tumor cell-derived small apoptotic our bodies. Adv Sci (Weinh). 2021;8(13):2004929.
Samos J, García-Olmo DC, Picazo MG, Rubio-Vitaller A, García-Olmo D. Circulating nucleic acids in plasma/serum and tumor development: are apoptotic our bodies concerned? An experimental examine in a rat most cancers mannequin. Ann N Y Acad Sci. 2006;1075:165–73.
Ford CA, Petrova S, Pound JD, Voss JJ, Melville L, Paterson M, Farnworth SL, Gallimore AM, Cuff S, Wheadon H, Dobbin E, Ogden CA, Dumitriu IE, Dunbar DR, Murray PG, Ruckerl D, Allen JE, Hume DA, van Rooijen N, Goodlad JR, Freeman TC, Gregory CD. Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma. Curr Biol. 2015;25(5):577–88.
Huang Q, Li F, Liu X, Li W, Shi W, Liu FF, O’Sullivan B, He Z, Peng Y, Tan AC, Zhou L, Shen J, Han G, Wang XJ, Thorburn J, Thorburn A, Jimeno A, Raben D, Bedford JS, Li CY. Caspase 3-mediated stimulation of tumor cell repopulation throughout most cancers radiotherapy. Nat Med. 2011;17(7):860–6.
Obenauf AC, Zou Y, Ji AL, Vanharanta S, Shu W, Shi H, Kong X, Bosenberg MC, Wiesner T, Rosen N, Lo RS, Massagué J. Remedy-induced tumour secretomes promote resistance and tumour development. Nature. 2015;520(7547):368–72.
Rapoport EM, Sapot’ko YB, Pazynina GV, Bojenko VK, Bovin NV. Sialoside-binding macrophage lectins in phagocytosis of apoptotic our bodies. Biochemistry. 2005;70(3):330–8.
Aihara M, Truong LD, Dunn JK, Wheeler TM, Scardino PT, Thompson TC. Frequency of apoptotic our bodies positively correlates with Gleason grade in prostate most cancers. Hum Pathol. 1994;25(8):797–801.
Pavlyukov MS, Yu H, Bastola S, Minata M, Shender VO, Lee Y, Zhang S, Wang J, Komarova S, Wang J, Yamaguchi S, Alsheikh HA, Shi J, Chen D, Mohyeldin A, Kim SH, Shin YJ, Anufrieva Ok, Evtushenko EG, Antipova NV, Arapidi GP, Govorun V, Pestov NB, Shakhparonov MI, Lee LJ, Nam DH, Nakano I. Apoptotic cell-derived extracellular vesicles promote malignancy of glioblastoma through intercellular switch of splicing elements. Most cancers Cell. 2018;34(1):119–35.
Zweemer AJM, French CB, Mesfin J, Gordonov S, Meyer AS, Lauffenburger DA. Apoptotic our bodies elicit Gas6-mediated migration of AXL-expressing tumor cells. Mol Most cancers Res. 2017;15(12):1656–66.
Muhsin-Sharafaldine MR, Saunderson SC, Dunn AC, Faed JM, Kleffmann T, McLellan AD. Procoagulant and immunogenic properties of melanoma exosomes, microvesicles and apoptotic vesicles. Oncotarget. 2016;7(35):56279–94.
Muhsin-Sharafaldine MR, Kennedy BR, Saunderson SC, Buchanan CR, Dunn AC, Faed JM, McLellan AD. Mechanistic perception into the procoagulant exercise of tumor-derived apoptotic vesicles. Biochim Biophys Acta Gen Subj. 2017;1861(2):286–95.
Horrevorts SK, Stolk DA, van de Ven R, Hulst M, van Het Hof B, Duinkerken S, Heineke MH, Ma W, Dusoswa SA, Nieuwland R, Garcia-Vallejo JJ, van de Loosdrecht AA, de Gruijl TD, van Vliet SJ, van Kooyk Y. Glycan-modified apoptotic melanoma-derived extracellular vesicles as antigen supply for anti-tumor vaccination. Cancers. 2019;11(9):1266.
Aydin H, Zhou M, Herawi M, Epstein JI. Quantity and placement of nucleoli and presence of apoptotic our bodies in diagnostically difficult instances of prostate adenocarcinoma on needle biopsy. Hum Pathol. 2005;36(11):1172–7.
Fu X, Liu G, Halim A, Ju Y, Luo Q, Tune AG. Mesenchymal stem cell migration and tissue restore. Cells. 2019;8(8):784.
Attia N, Mashal M. Mesenchymal stem cells: the previous current and future. Adv Exp Med Biol. 2021;1312:107–29.
Lan T, Luo M, Wei X. Mesenchymal stem/stromal cells in most cancers remedy. J Hematol Oncol. 2021;14(1):195.
Ha DH, Kim HK, Lee J, Kwon HH, Park GH, Yang SH, Jung JY, Choi H, Lee JH, Sung S, Yi YW, Cho BS. Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and pores and skin regeneration. Cells. 2020;9(5):1157.
Fu Y, Sui B, Xiang L, Yan X, Wu D, Shi S, Hu X. Rising understanding of apoptosis in mediating mesenchymal stem cell remedy. Cell Demise Dis. 2021;12(6):596.
Ma L, Chen C, Liu D, Huang Z, Li J, Liu H, Kin Kwok RT, Tang B, Sui B, Zhang X, Tang J, Mao X, Huang W, Shi S, Kou X. Apoptotic extracellular vesicles are metabolized regulators nurturing the pores and skin and hair. Bioact Mater. 2023;19:626–41.
Zhang X, Tang JX, Kou XX, Huang WY, Zhu Y, Jiang YH, Yang KK, Li C, Hao M, Qu Y, Ma L, Chen C, Shi ST, Zhou YS. Proteomic evaluation of MSC-derived apoptotic vesicles identifies Fas inheritance to ameliorate haemophilia a through activating platelet features. J Extracell Vesicles. 2022;11(7): e12240.
Veerman RE, Güçlüler Akpinar G, Eldh M, Gabrielsson S. Immune Cell-derived extracellular vesicles – features and therapeutic functions. Tendencies Mol Med. 2019;25(5):382–94.
Zhu Z, Zhang D, Lee H, Menon AA, Wu J, Hu Ok, Jin Y. Macrophage-derived apoptotic our bodies promote the proliferation of the recipient cells through shuttling microRNA-221/222. J Leukoc Biol. 2017;101(6):1349–59.
Kubicka-Sierszen A, Grzegorczyk J. The affect of infectious elements on dendritic cell apoptosis. Arch Med Sci. 2015;11(5):1044–51.
Serrano-Heras G, Díaz-Maroto I, Castro-Robles B, Carrión B, Perona-Moratalla AB, Gracia J, Arteaga S, Hernández-Fernández F, García-García J, Ayo-Martín O, Segura T. Isolation and quantification of blood apoptotic our bodies, a non-invasive device to judge apoptosis in sufferers with ischemic stroke and neurodegenerative ailments. Biol Proced On-line. 2020;22:17.
Tian J, Wang Y, Ding M, Zhang Y, Chi J, Wang T, Jiao B, Jian Z, Yi X, Huang Y, Liu L, Li Ok, Chen J, Wang G, Gao T, Li C, Li Q. The Formation of melanocyte apoptotic our bodies in vitiligo and the relocation of vitiligo autoantigens beneath oxidative stress. Oxid Med Cell Longev. 2021;2021:7617839.
Marin-Gallen S, Clemente-Casares X, Planas R, Pujol-Autonell I, Carrascal J, Carrillo J, Ampudia R, Verdaguer J, Pujol-Borrell R, Borràs FE, Vives-Pi M. Dendritic cells pulsed with antigen-specific apoptotic our bodies stop experimental kind 1 diabetes. Clin Exp Immunol. 2010;160(2):207–14.
Tyukavin AI, Belostotskaya GB, Golovanova TA, Galagudza MM, Zakharov EA, Burkova NV, Ivkin DY, Karpov AA. Stimulation of proliferation and differentiation of rat resident myocardial cells with apoptotic our bodies of cardiomyocytes. Bull Exp Biol Med. 2015;159(1):138–41.
Jiang JX, Mikami Ok, Venugopal S, Li Y, Török NJ. Apoptotic physique engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways. J Hepatol. 2009;51(1):139–48.
Ma Q, Liang M, Limjunyawong N, Dan Y, Xing J, Li J, Xu J, Dou C. Osteoclast-derived apoptotic our bodies present prolonged organic results of parental cell in selling bone defect therapeutic. Theranostics. 2020;10(15):6825–38.
Kakarla R, Hur J, Kim YJ, Kim J, Chwae YJ. Apoptotic cell-derived exosomes: messages from dying cells. Exp Mol Med. 2020;52(1):1–6.
Phan TK, Ozkocak DC, Poon IKH. Unleashing the therapeutic potential of apoptotic our bodies. Biochem Soc Trans. 2020;48(5):2079–88.
Karamchandani DM, Chetty R. Apoptotic colopathy: a practical strategy to analysis. J Clin Pathol. 2018;71(12):1033–40.
Lee M, Betman S, Iuga A, Yang HM, Fleming J, Inexperienced PHR, Lebwohl B, Lagana SM. An affiliation between crypt apoptotic our bodies and mucosal flattening in celiac illness sufferers uncovered to dietary gluten. Diagn Pathol. 2019;14(1):98.
Hakim SA, Abd E-Ok. Analysis of crypt apoptotic our bodies and apoptotic indices in pediatric celiac illness by routine staining and H2AX immunostaining. Int J Immunopathol Pharmacol. 2021;35:20587384211026790.
Kawashima T, Doh-ura Ok, Ogomori Ok, Iwaki T. Apoptotic our bodies within the cerebellum of Japanese sufferers with Creutzfeldt-Jakob illness. Pathol Int. 2001;51(3):140–4.
Honrado C, Adair SJ, Moore JH, Salahi A, Bauer TW, Swami NS. Apoptotic our bodies within the pancreatic tumor cell tradition media allow label-free drug sensitivity evaluation by impedance cytometry. Adv Biol. 2021;5(8): e2100438.
Lin J, Fan R, Zhao Z, Cummings OW, Chen S. Is the presence of 6 or fewer crypt apoptotic our bodies enough for analysis of graft versus host illness? A decade of expertise at a single establishment. Am J Surg Pathol. 2013;37(4):539–47.
Akpek G, Chinratanalab W, Lee LA, Torbenson M, Hallick JP, Anders V, Vogelsang GB. Gastrointestinal involvement in persistent graft-versus-host illness: a clinicopathologic examine. Biol Blood Marrow Transpl. 2003;9(1):46–51.
Broughton BR, Reutens DC, Sobey CG. Apoptotic mechanisms after cerebral ischemia. Stroke. 2009;40(5):e331–9.
Ghavami S, Shojaei S, Yeganeh B, Ande SR, Jangamreddy JR, Mehrpour M, Christoffersson J, Chaabane W, Moghadam AR, Kashani HH, Hashemi M, Owji AA, Łos MJ. Autophagy and apoptosis dysfunction in neurodegenerative issues. Prog Neurobiol. 2014;112:24–49.
Masvekar R, Mizrahi J, Park J, Williamson PR, Bielekova B. Quantifications of CSF apoptotic our bodies don’t present scientific worth in a number of sclerosis. Entrance Neurol. 2019;10:1241.
Mégret F, Prehaud C, Lafage M, Batejat C, Escriou N, Lay S, Thoulouze MI, Lafon M. Immunopotentiation of the antibody response in opposition to influenza HA with apoptotic our bodies generated by rabies virus G-ERA protein-driven apoptosis. Vaccine. 2005;23(46–47):5342–50.
Adamson L, Palma M, Choudhury A, Eriksson I, Näsman-Glaser B, Hansson M, Hansson L, Kokhaei P, Osterborg A, Mellstedt H. Era of a dendritic cell-based vaccine in persistent lymphocytic leukaemia utilizing CliniMACS platform for large-scale manufacturing. Scand J Immunol. 2009;69(6):529–36.
Chevallier P, Saiagh S, Dehame V, Guillaume T, Peterlin P, Bercegeay S, Le Bris Y, Bossard C, Gauvrit I, Dreno B, Juge-Morineau N, Béné MC, Gregoire M. A part I/II feasibility vaccine examine by autologous leukemic apoptotic corpse-pulsed dendritic cells for aged AML sufferers. Hum Vaccin Immunother. 2021;17(10):3511–4.
Hus I, Roliński J, Tabarkiewicz J, Wojas Ok, Bojarska-Junak A, Greiner J, Giannopoulos Ok, Dmoszyńska A, Schmitt M. Allogeneic dendritic cells pulsed with tumor lysates or apoptotic our bodies as immunotherapy for sufferers with early-stage B-cell persistent lymphocytic leukemia. Leukemia. 2005;19(9):1621–7.
Faridnia R, Kalani H, Hezarjaribi HZ, Denny PW, Rafie A, Fakhar M, Virgilio S. Apoptotic blebs from Leishmania major-infected macrophages as a brand new strategy for cutaneous leishmaniasis vaccination. Microb Pathog. 2020;147: 104406.
Fond AM, Ravichandran KS. Clearance of dying cells by phagocytes: mechanisms and implications for illness pathogenesis. Adv Exp Med Biol. 2016;930:25–49.
Medina CB, Ravichandran KS. Don’t let demise do us half: “find-me” indicators in communication between dying cells and the phagocytes. Cell Demise Differ. 2016;23(6):979–89.
Arandjelovic S, Ravichandran KS. Phagocytosis of apoptotic cells in homeostasis. Nat Immunol. 2015;16(9):907–17.
Poon IK, Lucas CD, Rossi AG, Ravichandran KS. Apoptotic cell clearance: primary biology and therapeutic potential. Nat Rev Immunol. 2014;14(3):166–80.
Cohen PL, Caricchio R, Abraham V, Camenisch TD, Jennette JC, Roubey RA, Earp HS, Matsushima G, Reap EA. Delayed apoptotic cell clearance and lupus-like autoimmunity in mice missing the c-mer membrane tyrosine kinase. J Exp Med. 2002;196(1):135–40.
Kojima Y, Volkmer JP, McKenna Ok, Civelek M, Lusis AJ, Miller CL, Direnzo D, Nanda V, Ye J, Connolly AJ, Schadt EE, Quertermous T, Betancur P, Maegdefessel L, Matic LP, Hedin U, Weissman IL, Leeper NJ. CD47-blocking antibodies restore phagocytosis and stop atherosclerosis. Nature. 2016;536(7614):86–90.
Holmgren L, Szeles A, Rajnavolgyi E, Folkman J, Klein G, Ernberg I, Falk KI. Horizontal switch of DNA by the uptake of apoptotic our bodies. Blood. 1999;93(11):3956–63.
Bergsmedh A, Szeles A, Henriksson M, Bratt A, Folkman MJ, Spetz AL, Holmgren L. Horizontal switch of oncogenes by uptake of apoptotic our bodies. Proc Natl Acad Sci USA. 2001;98(11):6407–11.
Black LV, Saunderson SC, Coutinho FP, Muhsin-Sharafaldine MR, Damani TT, Dunn AC, McLellan AD. The CD169 sialoadhesin molecule mediates cytotoxic T-cell responses to tumour apoptotic vesicles. Immunol Cell Biol. 2016;94(5):430–8.
Xie Y, Bai O, Yuan J, Chibbar R, Slattery Ok, Wei Y, Deng Y, Xiang J. Tumor apoptotic our bodies inhibit CTL responses and antitumor immunity through membrane-bound reworking development factor-beta1 inducing CD8+ T-cell anergy and CD4+ Tr1 cell responses. Most cancers Res. 2009;69(19):7756–66.
Lynch C, Panagopoulou M, Gregory CD. Extracellular vesicles arising from apoptotic cells in tumors: roles in most cancers pathogenesis and potential scientific functions. Entrance Immunol. 2017;8:1174.
Kokhaei P, Choudhury A, Mahdian R, Lundin J, Moshfegh A, Osterborg A, Mellstedt H. Apoptotic tumor cells are superior to tumor cell lysate, and tumor cell RNA in induction of autologous T cell response in B-CLL. Leukemia. 2004;18(11):1810–5.
Kokhaei P, Rezvany MR, Virving L, Choudhury A, Rabbani H, Osterborg A, Mellstedt H. Dendritic cells loaded with apoptotic tumour cells induce a stronger T-cell response than dendritic cell-tumour hybrids in B-CLL. Leukemia. 2003;17(5):894–9.
Holmgren L, Bergsmedh A, Spetz AL. Horizontal switch of DNA by the uptake of apoptotic our bodies. Vox Sang. 2002;83(Suppl 1):305–6.
Henry F, Bretaudeau L, Barbieux I, Meflah Ok, Gregoire M. Induction of antigen presentation by macrophages after phagocytosis of tumour apoptotic cells. Res Immunol. 1998;149(7–8):673–9.
Gautier F, Irminger-Finger I, Grégoire M, Meflah Ok, Harb J. Identification of an apoptotic cleavage product of BARD1 as an autoantigen: a possible issue within the antitumoral response mediated by apoptotic our bodies. Most cancers Res. 2000;60(24):6895–900.
Ma Z, Wang Y, Li H. Purposes of extracellular vesicles in tissue regeneration. Biomicrofluidics. 2020;14(1): 011501.
Einhorn TA, Gerstenfeld LC. Fracture therapeutic: mechanisms and interventions. Nat Rev Rheumatol. 2015;11(1):45–54.
Yang S, Wang N, Ma Y, Guo S, Guo S, Solar H. Immunomodulatory results and mechanisms of distraction osteogenesis. Int J Oral Sci. 2022;14(1):4.
Landry P, Sadasivan Ok, Marino A, Albright J. Apoptosis is coordinately regulated with osteoblast formation throughout bone therapeutic. Tissue Cell. 1997;29(4):413–9.
Olmedo ML, Landry PS, Sadasivan KK, Albright JA, Marino AA. Programmed cell demise in post-traumatic bone callus. Cell Mol Biol. 2000;46(1):89–97.
Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN, Deo R, de Ferranti SD, Ferguson JF, Fornage M, Gillespie C, Isasi CR, Jimenez MC, Jordan LC, Judd SE, Lackland D, Lichtman JH, Lisabeth L, Liu S, Longenecker CT, Lutsey PL, Mackey JS, Matchar DB, Matsushita Ok, Mussolino ME, Nasir Ok, O’Flaherty M, Palaniappan LP, Pandey A, Pandey DK, Reeves MJ, Ritchey MD, Rodriguez CJ, Roth GA, Rosamond WD, Sampson UKA, Satou GM, Shah SH, Spartano NL, Tirschwell DL, Tsao CW, Voeks JH, Willey JZ, Wilkins JT, Wu JH, Alger HM, Wong SS, Muntner P, American Coronary heart Affiliation Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Coronary heart Illness and Stroke Statistics-2018 Replace: a report from the American Coronary heart Affiliation. Circulation. 2018;137(12):e67–492.
Cui H, Miao S, Esworthy T, Zhou X, Lee SJ, Liu C, Yu ZX, Fisher JP, Mohiuddin M, Zhang LG. 3D bioprinting for cardiovascular regeneration and pharmacology. Adv Drug Deliv Rev. 2018;132:252–69.
Zhang Y, Mignone J, MacLellan WR. Cardiac regeneration and stem cells. Physiol Rev. 2015;95(4):1189–204.
Hristov M, Erl W, Linder S, Weber PC. Apoptotic our bodies from endothelial cells improve the quantity and provoke the differentiation of human endothelial progenitor cells in vitro. Blood. 2004;104(9):2761–6.
Zernecke A, Bidzhekov Ok, Noels H, Shagdarsuren E, Gan L, Denecke B, Hristov M, Köppel T, Jahantigh MN, Lutgens E, Wang S, Olson EN, Schober A, Weber C. Supply of microRNA-126 by apoptotic our bodies induces CXCL12-dependent vascular safety. Sci Sign. 2009;2(100): ra81.
Tyukavin AI, Belostotskaya GB, Zakharov EA, Ivkin DY, Radko SV, Knyazev NA, Klimenko VV, Bogdanov AA, Suchkov SV. Apoptotic our bodies of cardiomyocytes and fibroblasts – regulators of directed differentiation of coronary heart stem cells. Bull Exp Biol Med. 2020;170(1):112–7.
Brock CK, Wallin ST, Ruiz OE, Samms KM, Mandal A, Sumner EA, Eisenhoffer GT. Stem cell proliferation is induced by apoptotic our bodies from dying cells throughout epithelial tissue upkeep. Nat Commun. 2019;10(1):1044.
Li F, Huang Q, Chen J, Peng Y, Roop DR, Bedford JS, Li CY. Apoptotic cells activate the “phoenix rising” pathway to advertise wound therapeutic and tissue regeneration. Sci Sign. 2010;3(110): ra13.
Feng X, Tian L, Zhang Z, Yu Y, Cheng J, Gong Y, Li CY, Huang Q. Caspase 3 in dying tumor cells mediates post-irradiation angiogenesis. Oncotarget. 2015;6(32):32353–67.
Feng X, Yu Y, He S, Cheng J, Gong Y, Zhang Z, Yang X, Xu B, Liu X, Li CY, Tian L, Huang Q. Dying glioma cells set up a proangiogenic microenvironment by a caspase 3 dependent mechanism. Most cancers Lett. 2017;385:12–20.
Chera S, Ghila L, Dobretz Ok, Wenger Y, Bauer C, Buzgariu W, Martinou JC, Galliot B. Apoptotic cells present an surprising supply of Wnt3 signaling to drive hydra head regeneration. Dev Cell. 2009;17(2):279–89.
Galliot B, Chera S. The Hydra mannequin: disclosing an apoptosis-driven generator of Wnt-based regeneration. Tendencies Cell Biol. 2010;20(9):514–23.
Chera S, Ghila L, Wenger Y, Galliot B. Harm-induced activation of the MAPK/CREB pathway triggers apoptosis-induced compensatory proliferation in hydra head regeneration. Dev Development Differ. 2011;53(2):186–201.
Zhao D, Tao W, Li S, Chen Y, Solar Y, He Z, Solar B, Solar J. Apoptotic body-mediated intercellular supply for enhanced drug penetration and entire tumor destruction. Sci Adv. 2021;7(16): eabg0880.
Liu Y, Wang J, Zhang J, Marbach S, Xu W, Zhu L. Concentrating on tumor-associated macrophages by MMP2-sensitive apoptotic body-mimicking nanoparticles. ACS Appl Mater Interfaces. 2020;12(47):52402–14.
Boisteau O, Gautier F, Cordel S, Henry F, Harb J, Douillard JY, Vallette FM, Meflah Ok, Grégoire M. Apoptosis induced by sodium butyrate therapy will increase immunogenicity of a rat colon tumor cell line. Apoptosis. 1997;2(4):403–12.
Gou J, Li H, Bi J, Pang X, Li X, Wang Y. Switch of IGF2BP3 by Ara-C-induced apoptotic our bodies promotes survival of recipient cells. Entrance Oncol. 2022;12: 801226.
Bao P, Zheng ZT, Ye JJ, Zhang XZ. Apoptotic body-mediated intracellular supply technique for enhanced STING activation and improved tumor immunogenicity. Nano Lett. 2022;22(6):2217–27.
Dou G, Tian R, Liu X, Yuan P, Ye Q, Liu J, Liu S, Zhou J, Deng Z, Chen X, Liu S, Jin Y. Chimeric apoptotic our bodies functionalized with pure membrane and modular supply system for irritation modulation. Sci Adv. 2020;6(30): eaba2987.
Whiteside TL, Piazza P, Reiter A, Stanson J, Connolly NC, Rinaldo CR Jr, Riddler SA. Manufacturing of a dendritic cell-based vaccine containing inactivated autologous virus for remedy of sufferers with persistent human immunodeficiency virus kind 1 an infection. Clin Vaccine Immunol. 2009;16(2):233–40.
Macatangay BJ, Riddler SA, Wheeler ND, Spindler J, Lawani M, Hong F, Buffo MJ, Whiteside TL, Kearney MF, Mellors JW, Rinaldo CR. Therapeutic vaccination with dendritic cells loaded with autologous HIV kind 1-infected apoptotic cells. J Infect Dis. 2016;213(9):1400–9.
Frleta D, Ochoa CE, Kramer HB, Khan SA, Stacey AR, Borrow P, Kessler BM, Haynes BF, Bhardwaj N. HIV-1 infection-induced apoptotic microparticles inhibit human DCs through CD44. J Clin Make investments. 2012;122(12):4685–97.
Aprahamian T, Takemura Y, Goukassian D, Walsh Ok. Ageing is related to diminished apoptotic cell clearance in vivo. Clin Exp Immunol. 2008;152(3):448–55.
Plowden J, Renshaw-Hoelscher M, Engleman C, Katz J, Sambhara S. Innate immunity in getting older: influence on macrophage operate. Growing old Cell. 2004;3(4):161–7.
Armstrong JP, Holme MN, Stevens MM. Re-engineering extracellular vesicles as good nanoscale therapeutics. ACS Nano. 2017;11(1):69–83.
Zhou M, Li YJ, Tang YC, Hao XY, Xu WJ, Xiang DX, Wu JY. Apoptotic our bodies for superior drug supply and remedy. J Management Launch. 2022;351:394–406.
de Jong OG, Kooijmans SAA, Murphy DE, Jiang L, Evers MJW, Sluijter JPG, Vader P, Schiffelers RM. Drug supply with extracellular vesicles: from creativeness to innovation. Acc Chem Res. 2019;52(7):1761–70.
Mi B, Chen L, Xiong Y, Yang Y, Panayi AC, Xue H, Hu Y, Yan C, Hu L, Xie X, Lin Z, Zhou W, Cao F, Xiao X, Feng Q, Liu G. Osteoblast/osteoclast and immune cocktail remedy of an exosome/drug supply multifunctional hydrogel accelerates fracture restore. ACS Nano. 2022;16(1):771–82.
Jun I, Lee YB, Choi YS, Engler AJ, Park H, Shin H. Switch stamping of human mesenchymal stem cell patches utilizing thermally expandable hydrogels with tunable cell-adhesive properties. Biomaterials. 2015;54:44–54.
Kretlow JD, Klouda L, Mikos AG. Injectable matrices and scaffolds for drug supply in tissue engineering. Adv Drug Deliv Rev. 2007;59(4–5):263–73.
Galarraga JH, Locke RC, Witherel CE, Stoeckl BD, Castilho M, Mauck RL, Malda J, Levato R, Burdick JA. Fabrication of MSC-laden composites of hyaluronic acid hydrogels bolstered with MEW scaffolds for cartilage restore. Biofabrication. 2021;14(1): 014106.
Koev TT, Harris HC, Kiamehr S, Khimyak YZ, Warren FJ. Starch hydrogels as focused colonic drug supply autos. Carbohydr Polym. 2022;289: 119413.
Sato YT, Umezaki Ok, Sawada S, Mukai SA, Sasaki Y, Harada N, Shiku H, Akiyoshi Ok. Engineering hybrid exosomes by membrane fusion with liposomes. Sci Rep. 2016;6:21933.