Poly(ethylene glycol) (PEG) is the gold commonplace used to scale back unspecific protein adsorption and extend nanocarrier circulation time. Nevertheless, this stealth impact may very well be counteracted by the rising prevalence of anti-PEG antibodies within the bloodstream. Thus far, the presence of anti-PEG antibodies within the protein corona and their impact on cell uptake has not been investigated but. Our outcomes confirmed a excessive focus and prevalence of anti-PEG antibodies within the German inhabitants. PEGylated nanocarriers exhibited the next stage of anti-PEG antibodies within the protein corona in comparison with non-PEGylated, which result in larger uptake in macrophages. Consequently, the anti-PEG antibodies within the protein corona may mitigate the stealth impact of PEG, resulting in accelerated blood clearance and undesirable unwanted side effects.
