Podophyllotoxin (PPT), an aryltetralin-type lignan remoted from Podophyllum species, displays a variety of biologic and pharmacologic actions, and primarily serves as an antiviral agent or antitumor drug in scientific functions.
Nevertheless, the therapeutic potential of PPT has been hindered attributable to its detrimental systemic toxicity, poor solubility, and bioavailability. Nanoparticles, which preferentially accumulate in tumors by enhanced permeability and retention results, have develop into helpful instruments for focused drug supply, thus securing a distinct segment in most cancers therapies.
The nano-based drug supply platform has been launched to PPT supply for the aim of improved solubility, enhanced efficacy, and decreased toxicity. For many years, intensive efforts have been devoted to designing and growing varied PPT supply techniques to mitigate undesirable toxicity and increase scientific applicability.
The authors of a brand new article revealed in Acta Materia Medica assessment the newest achievements in PPT supply patterns and pharmacodynamic considerations with the expectation of shedding gentle on future analysis and potential functions of PPT.
Extra info:
Chaozheng Zhang et al, Advances in nanoscale carrier-based approaches to scale back toxicity and improve efficacy of podophyllotoxin, Acta Materia Medica (2023). www.scienceopen.com/hosted-doc … .15212/AMM-2023-0038
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Advances in nanoscale carrier-based approaches to boost efficacy of podophyllotoxin (2023, December 13)
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