Hoy D, March L, Brooks P, Blyth F, Woolf A, Bain C, Williams G, Smith E, Vos T, Barendregt J, et al. The worldwide burden of low again ache: estimates from the World Burden of Illness 2010 research. Ann Rheum Dis. 2014;73:968–74.
Goodman DM, Burke AE, Livingston EH. JAMA affected person web page. Low again ache JAMA. 2013;309:1738.
Knezevic NN, Candido KD, Vlaeyen JWS, Van Zundert J, Cohen SP. Low again ache. Lancet. 2021;398:78–92.
Morlion B. Persistent low again ache: pharmacological, interventional and surgical methods. Nat Rev Neurol. 2013;9:462–73.
Fenton-White HA. Trailblazing: the historic improvement of the posterior lumbar interbody fusion (PLIF). Backbone J. 2021;21:1528–41.
Pan M, Li Q, Li S, Mao H, Meng B, Zhou F, Yang H. Percutaneous endoscopic lumbar discectomy: indications and problems. Ache Phys. 2020;23:49–56.
Zhang X, Hu Y, Hao D, Li T, Jia Y, Hu W, Xu Z. New methods for the remedy of intervertebral disc degeneration: cell, exosome, gene, and tissue engineering. Am J Transl Res. 2022;14:8031–48.
Risbud MV, Shapiro IM. Function of cytokines in intervertebral disc degeneration: ache and disc content material. Nat Rev Rheumatol. 2014;10:44–56.
Francisco V, Pino J, Gonzalez-Homosexual MA, Lago F, Karppinen J, Tervonen O, Mobasheri A, Gualillo O. A brand new immunometabolic perspective of intervertebral disc degeneration. Nat Rev Rheumatol. 2022;18:47–60.
Gao B, Jiang B, Xing W, Xie Z, Luo Z, Zou W. Discovery and utility of postnatal nucleus pulposus progenitors important for intervertebral disc homeostasis and degeneration. Adv Sci (Weinh). 2022;9:e2104888.
Hu B, Lv X, Wei L, Wang Y, Zheng G, Yang C, Zang F, Wang J, Li J, Wu X, et al. Sensory nerve maintains intervertebral disc extracellular matrix homeostasis By way of CGRP/CHSY1 axis. Adv Sci (Weinh). 2022;9:e2202620.
Solar Okay, Jiang J, Wang Y, Solar X, Zhu J, Xu X, Solar J, Shi J. The function of nerve fibers and their neurotransmitters in regulating intervertebral disc degeneration. Ageing Res Rev. 2022;81:101733.
Liu W, Ma Z, Wang Y, Yang J. A number of nano-drug supply programs for intervertebral disc degeneration: present standing and future views. Bioact Mater. 2023;23:274–99.
Zhou X, Shen N, Tao Y, Wang J, Xia Okay, Ying L, Zhang Y, Huang X, Hua J, Liang C, et al. Nucleus pulposus cell-derived environment friendly microcarrier for intervertebral disc tissue engineering. Biofabrication. 2023;15:025008.
Li Z, Cai F, Tang J, Xu Y, Guo Okay, Xu Z, Feng Y, Xi Okay, Gu Y, Chen L. Oxygen metabolism-balanced engineered hydrogel microspheres promote the regeneration of the nucleus pulposus by inhibiting acid-sensitive complexes. Bioact Mater. 2023;24:346–60.
Chen T, Qian Q, Makvandi P, Zare EN, Chen Q, Chen L, Zhang Z, Zhou H, Zhou W, Wang H, et al. Engineered high-strength biohydrogel as a multifunctional platform to ship nucleic acid for ameliorating intervertebral disc degeneration. Bioact Mater. 2023;25:107–21.
Lim S, An SB, Jung M, Joshi HP, Kumar H, Kim C, Music SY, Lee JR, Kang M, Han I, Kim BS. Native supply of senolytic drug inhibits intervertebral disc degeneration and restores intervertebral disc construction. Adv Healthc Mater. 2022;11:e2101483.
Sakai D, Andersson GB. Stem cell remedy for intervertebral disc regeneration: obstacles and options. Nat Rev Rheumatol. 2015;11:243–56.
Lyu FJ, Cheung KM, Zheng Z, Wang H, Sakai D, Leung VY. IVD progenitor cells: a brand new horizon for understanding disc homeostasis and restore. Nat Rev Rheumatol. 2019;15:102–12.
Chen J, Zhu H, Xia J, Zhu Y, Xia C, Hu Z, Jin Y, Wang J, He Y, Dai J, Hu Z. Excessive-performance multi-dynamic bond cross-linked hydrogel with spatiotemporal siRNA supply for gene-cell mixture remedy of intervertebral disc degeneration. Adv Sci (Weinh). 2023;10:e2206306.
Peng B, Li Y. Considerations about cell remedy for intervertebral disc degeneration. NPJ Regen Med. 2022;7:46.
Oehme D, Goldschlager T, Ghosh P, Rosenfeld JV, Jenkin G. Cell-based therapies used to deal with lumbar degenerative disc illness: a scientific evaluate of animal research and human scientific trials. Stem Cells Int. 2015;2015:946031.
Huang YC, Leung VY, Lu WW, Luk KD. The results of microenvironment in mesenchymal stem cell-based regeneration of intervertebral disc. Backbone J. 2013;13:352–62.
Kass LE, Nguyen J. Nanocarrier-hydrogel composite supply programs for precision drug launch. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2022;14:e1756.
Cao H, Duan L, Zhang Y, Cao J, Zhang Okay. Present hydrogel advances in physicochemical and organic response-driven biomedical utility variety. Sign Transduct Goal Ther. 2021;6:426.
Tao B, Lin C, Qin X, Yu Y, Guo A, Li Okay, Tian H, Yi W, Lei D, Chen Y, Chen L. Fabrication of gelatin-based and Zn(2+)-incorporated composite hydrogel for accelerated contaminated wound therapeutic. Mater At the moment Bio. 2022;13:100216.
Li Y, Han Y, Wang X, Peng J, Xu Y, Chang J. Multifunctional hydrogels ready by twin ion cross-linking for persistent wound therapeutic. ACS Appl Mater Interfaces. 2017;9:16054–62.
Shi W, Fang F, Kong Y, Greer SE, Kuss M, Liu B, Xue W, Jiang X, Lovell P, Mohs AM, et al. Dynamic hyaluronic acid hydrogel with covalent linked gelatin as an anti-oxidative bioink for cartilage tissue engineering. Biofabrication. 2021;14(1):014107.
Lin S, Yin S, Shi J, Yang G, Wen X, Zhang W, Zhou M, Jiang X. Orchestration of vitality metabolism and osteogenesis by Mg(2+) facilitates low-dose BMP-2-driven regeneration. Bioact Mater. 2022;18:116–27.
Maguire D, Neytchev O, Talwar D, McMillan D, Shiels PG. Telomere homeostasis: interaction with magnesium. Int J Mol Sci. 2018;19(1):157.
Yamagami R, Bingaman JL, Frankel EA, Bevilacqua PC. Mobile situations of weakly chelated magnesium ions strongly promote RNA stability and catalysis. Nat Commun. 2018;9:2149.
Maier JA, Castiglioni S, Locatelli L, Zocchi M, Mazur A. Magnesium and irritation: advances and views. Semin Cell Dev Biol. 2021;115:37–44.
Zheltova AA, Kharitonova MV, Iezhitsa IN, Spasov AA. Magnesium deficiency and oxidative stress: an replace. Biomedicine (Taipei). 2016;6:20.
Wolf FI, Trapani V, Simonacci M, Ferre S, Maier JA. Magnesium deficiency and endothelial dysfunction: is oxidative stress concerned? Magnes Res. 2008;21:58–64.
Kurian AG, Singh RK, Patel KD, Lee JH, Kim HW. Multifunctional GelMA platforms with nanomaterials for superior tissue therapeutics. Bioact Mater. 2022;8:267–95.
Gao Q, Niu X, Shao L, Zhou L, Lin Z, Solar A, Fu J, Chen Z, Hu J, Liu Y, He Y. 3D printing of advanced GelMA-based scaffolds with nanoclay. Biofabrication. 2019;11:035006.
Zhang T, Wang Y, Li R, Xin J, Zheng Z, Zhang X, Xiao C, Zhang S. ROS-responsive magnesium-containing microspheres for antioxidative remedy of intervertebral disc degeneration. Acta Biomater. 2023;158:475–92.
Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Backbone (Phila Pa 1976). 2001;26:1873–8.
Lyu FJ, Cui H, Pan H, Mc Cheung Okay, Cao X, Iatridis JC, Zheng Z. Painful intervertebral disc degeneration and irritation: from laboratory proof to scientific interventions. Bone Res. 2021;9:7.
McHugh J. Linking cell mechanobiology and irritation in IVD degeneration. Nat Rev Rheumatol. 2020;16:604.
Fiorentini D, Cappadone C, Farruggia G, Prata C. Magnesium: biochemistry, diet, detection, and social affect of illnesses linked to its deficiency. Vitamins. 2021;13(4):1136.
Glasdam SM, Glasdam S, Peters GH. The significance of magnesium within the human physique: a scientific literature evaluate. Adv Clin Chem. 2016;73:169–93.
Kwesiga MP, Gillette AA, Razaviamri F, Plank ME, Canull AL, Alesch Z, He W, Lee BP, Guillory RJ 2nd. Biodegradable magnesium supplies regulate ROS-RNS steadiness in pro-inflammatory macrophage setting. Bioact Mater. 2023;23:261–73.
Sharikabad MN, Ostbye KM, Lyberg T, Brors O. Impact of extracellular Mg(2+) on ROS and Ca(2+) accumulation throughout reoxygenation of rat cardiomyocytes. Am J Physiol Coronary heart Circ Physiol. 2001;280:H344-353.
Xu C, Wang S, Wang H, Liu Okay, Zhang S, Chen B, Liu H, Tong F, Peng F, Tu Y, Li Y. Magnesium-based micromotors as hydrogen turbines for exact rheumatoid arthritis remedy. Nano Lett. 2021;21:1982–91.
Xu H, Solar M, Wang C, Xia Okay, Xiao S, Wang Y, Ying L, Yu C, Yang Q, He Y, et al. Progress differentiation factor-5-gelatin methacryloyl injectable microspheres laden with adipose-derived stem cells for restore of disc degeneration. Biofabrication. 2020;13:015010.
Yue Okay, Trujillo-de Santiago G, Alvarez MM, Tamayol A, Annabi N, Khademhosseini A. Synthesis, properties, and biomedical functions of gelatin methacryloyl (GelMA) hydrogels. Biomaterials. 2015;73:254–71.
Guo W, Douma L, Hu MH, Eglin D, Alini M, Secerovic A, Grad S, Peng X, Zou X, D’Este M, Peroglio M. Hyaluronic acid-based interpenetrating community hydrogel as a cell provider for nucleus pulposus restore. Carbohydr Polym. 2022;277:118828.
Inoue M, Isa ILM, Orita S, Suzuki-Narita M, Inage Okay, Shiga Y, Norimoto M, Umimura T, Sakai T, Eguchi Y, et al. An injectable hyaluronic acid hydrogel promotes intervertebral disc restore in a rabbit mannequin. Backbone (Phila Pa 1976). 2021;46:E810–6.
Yamamoto T, Suzuki S, Fujii T, Mima Y, Watanabe Okay, Matsumoto M, Nakamura M, Fujita N. Efficacy of hyaluronic acid on intervertebral disc irritation: an in vitro research utilizing notochordal cell strains and human disc cells. J Orthop Res. 2021;39:2197–208.
Mohd Isa IL, Abbah SA, Kilcoyne M, Sakai D, Dockery P, Finn DP, Pandit A. Implantation of hyaluronic acid hydrogel prevents the ache phenotype in a rat mannequin of intervertebral disc damage. Sci Adv. 2018;4:eaaq0597.
Zhou F, Hong Y, Liang R, Zhang X, Liao Y, Jiang D, Zhang J, Sheng Z, Xie C, Peng Z, et al. Fast printing of bio-inspired 3D tissue constructs for pores and skin regeneration. Biomaterials. 2020;258:120287.
Xiao L, Gao D, Zhang Y, Liu C, Yin Z. Codelivery of TGF-beta1 and anti-miR-141 by PLGA microspheres inhibits development of intervertebral disc degeneration. J Orthop Surg Res. 2023;18:17.
Cheng H, Guo Q, Zhao H, Liu Okay, Kang H, Gao F, Guo J, Yuan X, Hu S, Li F, et al. An injectable hydrogel scaffold loaded with dual-drug/sustained-release PLGA microspheres for the regulation of macrophage polarization within the remedy of intervertebral disc degeneration. Int J Mol Sci. 2022;24(1):390.
Henry N, Clouet J, Fragale A, Griveau L, Chedeville C, Veziers J, Weiss P, Le Bideau J, Guicheux J, Le Visage C. Pullulan microbeads/Si-HPMC hydrogel injectable system for the sustained supply of GDF-5 and TGF-beta1: new perception into intervertebral disc regenerative medication. Drug Deliv. 2017;24:999–1010.
Shen J, Chen A, Cai Z, Chen Z, Cao R, Liu Z, Li Y, Hao J. Exhausted native lactate accumulation through injectable nanozyme-functionalized hydrogel microsphere for irritation reduction and tissue regeneration. Bioact Mater. 2022;12:153–68.
Xia Okay, Zhu J, Hua J, Gong Z, Yu C, Zhou X, Wang J, Huang X, Yu W, Li L, et al. Intradiscal injection of induced pluripotent stem cell-derived nucleus pulposus-like cell-seeded polymeric microspheres promotes rat disc regeneration. Stem Cells Int. 2019;2019:6806540.
Vida C, Carracedo J, de Sequera P, Bodega G, Perez R, Alique M, Ramirez R. A excessive magnesium focus in citrate dialysate prevents oxidative stress and injury in human monocytes in vitro. Clin Kidney J. 2021;14:1403–11.
Guo Z, Zhang Z, Zhang N, Gao W, Li J, Pu Y, He B, Xie J. A Mg(2+)/polydopamine composite hydrogel for the acceleration of contaminated wound therapeutic. Bioact Mater. 2022;15:203–13.
Zhu Z, Yu Q, Li H, Han F, Guo Q, Solar H, Zhao H, Tu Z, Liu Z, Zhu C, Li B. Vanillin-based functionalization technique to assemble multifunctional microspheres for treating irritation and regenerating intervertebral disc. Bioact Mater. 2023;28:167–82.
Chen Q, Liang C, Solar X, Chen J, Yang Z, Zhao H, Feng L, Liu Z. H(2)O(2)-responsive liposomal nanoprobe for photoacoustic irritation imaging and tumor theranostics through in vivo chromogenic assay. Proc Natl Acad Sci U S A. 2017;114:5343–8.
