Silica nanoparticles have emerged as promising candidates within the discipline of nanomedicine resulting from their exceptional versatility and customizable properties. Nevertheless, issues about their potential toxicity in wholesome tissues and organs have hindered their widespread medical translation. To handle this problem, important consideration has been directed towards a selected subset of silica nanoparticles, particularly degradable silica nanoparticles, primarily due to their wonderful biocompatibility and responsive biodegradability. On this evaluate, we offer a complete understanding of degradable silica nanoparticles, categorizing them into two distinct teams: inorganic species-doped and natural moieties-doped silica nanoparticles primarily based on their framework elements. Subsequent, the latest progress of tumor microenvironment (TME)-responsive degradable silica nanoparticles for precision theragnostic functions is summarized intimately. Lastly, present bottlenecks and future alternatives of theranostic nanomedicines primarily based on degradable silica nanoparticles in medical functions are additionally outlined and mentioned. The goal of this complete evaluate is to make clear the potential of degradable silica nanoparticles in addressing present challenges in nanomedicine, providing insights into their design, functions in tumor prognosis and remedy, and paving the way in which for future developments in medical theranostic nanomedicines.
