As one of many main causes of world mortality, most cancers has prompted in depth analysis and growth to advance efficacious drug discovery, sustained drug supply and improved sensitivity in analysis. In the direction of these functions, nanofibers synthesized by electrospinning have exhibited nice medical potential as biomimetic tumor microenvironment mannequin for drug screening, a controllable platform for localized, extended drug launch, and a filtration know-how for seize and isolation of circulating tumor cells within the bloodstream. This evaluation offers an outline of utilized nanofiber design with give attention to versatile electrospinning fabrication strategies. The affect of topographical, bodily, and biochemical properties on the perform of nanofiber assemblies is mentioned, in addition to present and foreseeable boundaries to the medical translation of utilized nanofibers within the area of oncology.